Summer colds are a bummer. Studies in animals are inadequate or may be lacking, but available data show no evidence of an increased occurrence of fetal damage.US FDA pregnancy category Not Assigned: The US FDA has amended the pregnancy labeling rule for prescription drug products to require labeling that includes a summary of risk, a discussion of the data supporting that summary, and relevant information to help health care providers make prescribing decisions and counsel women about the use of drugs during pregnancy. Sinus Congestion and Pain Daytime Cool Ice, Vicks QlearQuil Daytime Sinus & Congestion, acetaminophen and phenylephrine Consumer Information, Benadryl Dosage Charts (Infants & Children), Cerner Multum, Inc. "UK Summary of Product Characteristics." Recent findings show that the use of a decongestant during the first trimester of pregnancy may raise the risk of certain rare birth defects in your unborn child. Is It Safe To Take a Bath While Pregnant? Substitution of phenylephrine for pseudoephedrine as a nasal decongestant. Also, avoid drinking grapefruit juice while taking this drug. Such side effects may include vomiting, temperature increase, and even coma, all of which you should seek emergency medical attention. They found no link between the medications and several other deformities that had been suggested by previous studies, such as clubfoot or defects of the eye or face, according to the report published in the American Journal of Epidemiology. Accessed July 15, 2022. Australian Drug Evaluation Committee "Prescribing medicines in pregnancy: an Australian categorisation of risk of drug use in pregnancy. This And phenylpropanolamine was linked to an eight times higher risk of defects of the ear and stomach. In most cases, pregnant women may be subjected to various Acetaminophen / phenylephrine is also known as: Alka-Seltzer Plus Cold and Sinus, Congespirin Aspirin Free, Contac Cold + Flu (Day Formula), D-Time Sinus, Day Relief Sinus PE, Dilotab II, Excedrin Sinus Headache, Mapap Sinus Congestion and Pain, Non-Pseudo Sinus Pain & Pressure, Robitussin Peak Cold Nasal Relief, Sinus Congestion and Pain Daytime Cool Ice, Sinutab Sinus Maximum Strength, Sudafed PE Sinus Pressure + Pain, Suphedrine PE Sinus Headache, Tylenol Plus Children's Cold & Stuffy Nose, Tylenol Sinus + Headache Day, Vicks QlearQuil Daytime Sinus & Congestion, Vicks Sinex Daytime. Take this medication exactly as prescribed by your doctor. are linked to rare birth defects of the digestive tract, ear and heart. Pseudoephedrine and phenylephrine belong to a class of drugs called alpha-adrenergic agonists, which cause the blood vessels to constrict. Animal studies are not available for the combination product. We all have encountered such complications countless times since childhood and may know some real-life hacks that have been used to deal with nasal congestion. A single copy of these materials may be reprinted for noncommercial personal use only. Pseudoephedrine and phenylephrine are not suitable for people taking a class of antidepressants called monoamine oxidase inhibitors (MAOIs). http://www.tga.gov.au/docs/html/medpreg.htm" (2010): "Product Information. Get prescriptions or refills through a video chat, if the doctor feels the prescriptions are medically appropriate. Phenylephrine is known to be relatively safe for breastfeeding women. But due to lack of adequate research on the subject, it is better to avoid its use whenever possible. So, no! It is not safe to use Phenylephrine while you are breastfeeding. Is It Safe To Take Antibiotics While Breastfeeding? Doctors refer to this as rhinitis medicamentosa, or rebound congestion. All flaired medical professionals on this subreddit are verified by the mods. We comply with the HONcode standard for trustworthy health information. By using our website, you consent to our use of cookies. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Medications can interact with certain foods. (2019). I recommend taking the highest effective dose for you of one or the other, not both. Glad you feel better, I took that two nights in a row and it's on my safe list from the hospital. http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT" (2013). The risk of an endocardial cushion defect among babies whose mothers did not take decongestants is about 3 per 10,000 live births.. Major birth defects of any kind affect about two to three percent of liveborn infants, so they are rare, study author Dr. Allen Mitchell said. Review/update the The associations we identified involved defects that generally affect less than 1 per 1,000 infants. Well, after taking the pill, I stupidly decide to do a search for each ingredient, and while all of the other ingredients were considered perfectly safe, there were not such good reviews for phenylephrine. Overuse of topical nasal decongestants can lead to chronic inflammation of the nasal passages. Video chat with a U.S. board-certified doctor 24/7 in less than one minute for common issues such as: colds and coughs, stomach symptoms, bladder infections, rashes, and more. Create an account to follow your favorite communities and start taking part in conversations. WebBackground: Fenfluramine was withdrawn from the U.S. market in 1997 because of its association with cardiac-valve abnormalities in adults. For these, please consult a doctor (virtually or in person). Toxicology Data Network. But in general, health care providers haven't seen those problems occur. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. An older study from 2003 investigated the effect of pseudoephedrine on milk production and the infants exposure through breast milk. It may be advised to get a doctors prescription or to avoid it altogether. What Pregnant People Need to Know About COVID-19, Pregnancy Pampering: What's Safe, What's Not, Relieving Cold Symptoms Without Toddler Cough Suppressants, COVID-19 Vaccine During Pregnancy: Everything Parents Should Know, The Best Allergy Medicines and Treatments for Kids. Ok, so I have read here on BBC that phenylephrine is generally ok in small ammounts during 2nd and 3rd trimesters, but I couldn't help but worry myself. Phenylephrine for injection is a prescription medication used to increase blood pressure during surgical procedures requiring anesthesia. Every fetus depends on the same blood flow for every essential function to form ultimately. However, it should always be determined whether the beneficial effects of treatment outweigh the possible risks for the developing fetus, van Gelder told Reuters Health. Cipla USA Inc. (2019): United States National Library of Medicine "Toxnet. Label: Nasal decongestant PE maximum strength non-drowsy- phenylephrine 10 mg tablet. The lowest possible dose required to achieve the desired effect should be used. Advertising revenue supports our not-for-profit mission. They carry several risks, depending on the stage of pregnancy: First trimester. The phenylephrine in Sudafed PE works by making your nasal passages blood vessels narrower, thus alleviating fluid flow into the nasal cavity. This medication page refers to the prescription form of phenylephrine. The prescription form of this medication comes in solution form that is instilled into the eye prior to examinations or procedures of the eye. BMJ. Learn more about effective methods in relieving congestion in toddlers and when to see a. Nasal congestion occurs when blood vessels within the sinuses and nasal passages become swollen and inflamed. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Tell your doctor if you have any side effect that bothers you or that does not go away. Phenylephrine Eccles, R. (2006). Some studies show a higher risk of birth defects with oral pseudoephedrine (Sudafed) and phenylephrine (Sudafed PE) during pregnancy. Call your doctor for medical advice about side effects. Signs and symptoms of SS can vary but may include: A person taking MAOIs needs to stop taking them for 14 days before starting a decongestant. 9 methods for relieving congestion in toddlers. privacy practices. What Are the Costs of a Multiple Pregnancy and Birth? Do not drive or operate heavy machinery until you know how phenylephrine affects you. Phenylephrine is not safe for consumption by pregnant women, especially in the first trimester of their pregnancy. It might feel convenient to take a decongestant in case of a cold or allergy, but it could have adverse effects on your babys development. All quotes delayed a minimum of 15 minutes. My doc and pharmacist said absolutely ZERO benedryl or any antihistamine. To avoid sleeping difficulties, individuals should avoid taking products that contain pseudoephedrine or phenylephrine before bed. It is not known if phenylephrine crosses into human milk. NEW YORK (Reuters Health) - A womans use of decongestant medications in the first trimester of pregnancy may raise her childs risk of certain rare birth defects, according to a small study. I wouldn't worry yourself. Please note that a response does not constitute a doctor-patient relationship. If you experience side effects, then stop using the drug, and see a Kaunitz AM. Diphenhydramine (this common drug may cause uterine contractions, so in the third trimester it should be used only under the direction of your doctor) The cough Nasal decongestants can cause some general side effects, the most common of which is insomnia. For potential or actual medical emergencies, immediately call 911 or your local emergency service. Eventually, that reduces the conditions to allow for normal breathing. The maximum recommended dose is 200 mcg for bolus injection and 200 mcg/min for infusion. Constriction of the blood vessels in the nose can provide short-term relief from nasal congestion. Ask your doctor or pharmacist for more information. Having a medical issue? Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. The recommended dose of phenylephrine for dilation of the pupil is 1 drop to the affected eye. They may recommend safer alternatives to help alleviate nasal congestion if required. That may reduce the amount of blood flowing into the uterus. accidentally took phenylephrine - i iluvsparkles Posted 12/10/09 Ok, so I have read here on BBC that phenylephrine is generally ok in small ammounts during Decongestants: Pseudoephedrine and phenylephrine (Sudafed, DayQuil, Claritin-D), especially if taken during the first trimester, may cause stomach defects or affect blood flowto the placenta though some doctors will recommend in limited amounts in the second and third trimesters. These work by constricting (narrowing) blood vessels. Could a monthly antibody injection be a promising endometriosis treatment? Our Standards: The Thomson Reuters Trust Principles. information is beneficial, we may combine your email and website usage information with Medically reviewed by Drugs.com. Australian Drug Evaluation Committee "Prescribing medicines in pregnancy: an Australian categorisation of risk of drug use in pregnancy. What are the best nasal decongestants for different ages? VAZCULEP- phenylephrine hydrochloride injection, DailyMed: Current Medication Information; U.S. National Library of Medicine. It is usually administered by a healthcare provider immediately prior to eye examinations or procedures. WebPhenylephrine Usage. To learn more, please visit our. Moms were asked what medications they took while pregnant and in the two months before becoming pregnant. When you visit this site, it may store or retrieve information on your browser, mostly in the form of cookies. Individuals can find phenylephrine in various over-the-counter medications for cold, flu, and allergy symptoms. i just called my doc on monday with another bad head cold and he said sudafed is on the safe list. This medication may be prescribed for other uses. Cold-like symptoms may make your nasal passage extremely congested. Immediate release: Take 60 mg every 46 hours, when needed. The manufacturer makes no recommendation regarding use during lactation.Excreted into human milk: UnknownExcreted into animal milk: Data not availableComments:-Animal data indicate this drug may decrease milk production. The narrowing of blood vessels in pregnant women may happen in the uterus, adversely affecting the fetus and causing congenital disabilities. (2020). 2023 The Heart & Brain. Pseudoephedrine and phenylephrine are pregnancy category C in all three trimesters of pregnancy. Do not drive or operate heavy machinery until you know how phenylephrine affects you. Phenylephrine may cause difficulty in falling asleep or staying asleep in some people ( 6 ). Overall, the safety of phenylephrine during pregnancy is not certain. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. This content does not have an English version. WebSide effects Pregnancy, breastfeeding and fertility Taking it with other medicines and herbal supplements Common questions Related conditions Allergies Common cold Cough Hay fever Sinusitis (sinus infection) Useful resources HealthUnlocked: Sudafed forum healthunlocked.com Allergy UK: charity www.allergyuk.org Phenylephrine may cause difficulty in falling asleep or staying asleep in some people ( 6 ). Understand though there is Sudafed (phenylephrine) and Sudafed (pseudoephedrine) I know pseudoephedrine is on my safe list but I really don't know about the other. The typical low-dose aspirin you can buy without a prescription is 81 mg. Low-dose aspirin is safe to use throughout pregnancy. However, if overdose is suspected, seek emergency medical attention. By posting, you are agreeing to our Terms of Use and understand that all information is taken at your own risk. Can i take phenylephrine and pseudoephedrine together? This is a potentially serious condition where the body produces too much of the neurochemical serotonin. The first-trimester use of phenylphrine was tied to an eight times higher risk of a heart defect called endocardial cushion defect. Can I take methylprednisolone with phenylephrine, Can i take phenylephrine with diphenhydramine. Every pregnancy starts out with a 3-5% chance of having a birth defect. Enter multiple addresses on separate lines or separate them with commas. During the first trimester, higher doses of aspirin may raise This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Phenylephrine Hydrochloride (phenylephrine)." We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. The common side effects may be less manifested and even easily tolerable over time as your body acclimates to Sudafed PE. i'm 5 months pregnant. Major Pharmaceuticals Inc (2019): United States National Library of Medicine "Toxnet. This drug should be used during pregnancy only if the benefit outweighs the risk to the fetus.AU TGA pregnancy category: B2US FDA pregnancy category: Not assigned Comments:-There is no data on use in pregnant women to know this drugs risks, including the risk of fetal harm or reproductive effects.-Acetaminophen is commonly used during pregnancy and has been assumed safe; recent data questions the safety, especially with routine use or varying genetics. By making your nasal passages blood vessels in pregnant women, especially in the nose can provide relief! To our Terms of use and understand that all information is taken at your own risk, alleviating... Suspected, seek emergency medical attention fetus depends on the stage of pregnancy: an australian of! 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All three trimesters of pregnancy it may store or retrieve information on your browser, mostly in First! Animal studies are not suitable for people taking a class of antidepressants monoamine... Prescription is 81 mg. low-dose aspirin is safe to use throughout pregnancy our website you... The phenylephrine in Sudafed PE it altogether `` Prescribing medicines in pregnancy an. Health System locations making your nasal passage extremely congested the body produces too much of the serotonin... Methylprednisolone with phenylephrine, can i take phenylephrine with diphenhydramine was withdrawn from the hospital suspected, seek medical. Of its association with cardiac-valve abnormalities in adults all three trimesters of pregnancy of the neurochemical.... Of pseudoephedrine on milk production and the infants exposure through breast milk usage with!