After reading all reviews, im taking no chances on giving The MED to my 9 mo old maltipoo rescue. Hes been on it for six months. Another call to vet asking for an appt - seems like an an emergency now? I gave my dog his first dose today and 6 hours later he was throwing up and became frantic to get outside to eat grass. Im switching back to the old stuff. Tuesday morning she woke up with horrible diarrhea. I went to zoetis and Expressed my views and they said the FDA report meant nothing and it was in America. Our boy Axel had been on Heartgard his entire life. Dr said either Simparica (best case scenario), GOLPP or brain tumor. I'm besides myself. Moxidectin was first approved by the FDA in 1997 for the prevention of heartworm disease in dogs. According to the FDA, Simparica Trio contains the following active ingredients: "Sarolaner was first approved by the FDA in 2016 to treat and control flea and tick infestations. It can also cause seizures and tremors, but those side effects are incredibly rare. My 6 year old Chihuahua has been on simparica trio for 4 days . and now i'm on an hour by hour let's see if she will perk up. If not, we had some success with symptom management using Prednisone. Now his tail looks like a rat tail. Today he had runny stools threw up mucus Wont eat or drink (i gave him ice out of my hand and did gove him couple treats) He is lethargic also I called emergency vet and ahe said it probably is from this medication but not all dogs have these side effects. This seemed like perfect treatment 3 in 1 but at what cost? 100% effective, zero side effects. after a few months of this i decided to go back to Sentinel and Bravecto. We rushed to the vets who said it had to be neurological and once I mentioned the diarrhea she looked into Simparica suspecting MDR1 with my dog. I hope the best for you and dog, I know its a tough time. I called the vet and she gave me anitdiarrhea medicine. I am terrified--wish I would of seen this sooner. My other two dogs had a little loose stool but nothing else. Hi, I was just wondering how long you continued on with the steroids with your puppy. In isolated cases, however, dogs displayed more serious reactions such as tremors, muscle twitching, and seizures. While she has not had seizures, trembling, or spasms, sometimes she just squeals and jumps up for no obvious reason. She went on 2 antibiotics, and medicated baths twice a week. So sorry to hear, and good for you in recognizing the problem! Simparica TRIO is a monthly chewable tablet that protects your dog against heartworm disease, five types of ticks, fleas, roundworms and hookworms. March 2016 saw the addition of Simparica, yet another so-called Isoxazoline flea and tick "remedy" and already several dogs have been adversely affected by this new drug. I will not be giving him simparica again. Im trying to understand how. Itching has decreased immensely. We administered the first dose on Wednesday June 1st to our 9 year old bouvier flanders. My American Akita puppy took this pill on August 8th. And how do we get the word out to everyone? Took her to her Vet where I was told she had another tremor. In addition to killing fleas and several kinds of ticks, Simparicais effective in preventing and treating mange and ear mites. Very dissapointed with my vet for not informing me of the risk this has on my dog. Gave my 4yr old lab/husky mix simpatico trio in April and then monthly after. I have always been apprehensive about putting my dog on Heartworm / Flea Tick medication because of horror stories, but I thought he's 5 and it will be from the vet and it seems like the responsible thing to do. They must get some kind of monetary bonus for only selling Simparica. We immediately gathered her up and took her to the vet. so what about her puppies I am so worried. I researched simparica after she started exhibiting problems and I have little doubt that this is what caused her problems. I stopped giving flea and tick medication all together since her dose in June that triggered the seizures. She is still eating but she is drinking more water. No side effects. They were taking Simperica for flea/tick and Heartguard to prevent heart worms. Generally, they may instruct you to administer it immediately when you remember and resume monthly dosing. Vet thought was inner ear infection now thinking otherwise. Just had my 1 yr old goldendoodle to the vet because he has had 3 seizures in the last month. I will never give him this drug again. But now I tell everyone just be aware that this product does have the potential to cause neurological harm. 5 hours after the dose she's home resting. I went to banfield hospital and they prescribed this medication for my dog and had thrown up non stop since he was given the pill and wouldnt eat anything and he passed away 10 days later (yesterday). I could never forgive myself. My vet gave us Simparica for my newly adopted Chihuahua yesterday. She continued to have seizures even she was on phenobarbital. She falls when she runs and when going up and down stairs. She's been fine since. It's definitely not! Hi how is your pup now? now seizures daily on all sorts of meds for it and the cost with medications to try and control seizures and vet visits and mainly seeing my once healthy playful full of life pups having seizures daily even in her sleep breaks my damn heart !!!!!!!!!!!!!! We are doing one more increase and if that doesnt help, we will be adding zonisamide. That being said I have had him tested for Heartworms (negative) and asked for him to be prescribed Trifexis - which he has been on since he was a puppy. About 11 months ago our vet recommended Simparica Trio. Now her dog is very sick and she has to take the dog to the vet every day in the past week. I gave this to my 8 yr old chihuahua and a couple days later he started having seizures. I suppose with any drug, during trials, there will be some who have side effects ranging from negligible to life threatening. Overview. My dog (6 years old) has been using monthly Simparica since I got him. She gave her a shot to keep her from throwing up and took her x-rays and told me to come back the next day if she wasn't better. Sarolaner (brand name Simparica) is used to treat and control flea and tick infestations in dogs. I am so sad to read what is happening to some pets. Stay safe! He had ONE dose that evening and completely lost his appetite within a couple days. For todays update the blood work came back MCH is low and Potassium is HI and Sodium is low. That evening after giving it to him he has puked various times. I sure hope he makes it! Hi Charlene, can you elaborate on agitated swallowing? Kind of ooze. Thank you all so much!!!! Vet did all kinds of tests but said it couldnt be simparica. I gave my dog simparica trio. And yeah he ate today 4 chicken breast and appeared to want it even better. This happened to our 2yr old frenchie last Friday. Do not give extra or double doses. On 08/06 she threw up. On Friday he was incredibly thirsty - he would drink a full bowl of water and then look at me for more. I gave our boy, Yogi his first dose of Simparica TRIO on 11/17/2020. She's a Brittany (Spaniel). Please anyone let me know if there is a class action law suit or where we can start one? Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). Hope all is well. His neck felt swollen and he was panting heavily gasping for air. He is stumbling, not able to stand on tile or go in and out of house without tripping on steps. Unfortunately, I didn't realize the tremors were possibly caused by the drug. We contacted the company using the phone number supplied in the under in the box and shared our experience with the new drug. I had placed an order with Pet Meds for the prescription before I saw any of these side effects.I will be returning this medication and order Heartgard and not sure what we will do for flea and ticks, since he turns his nos Simparica Trio, e to the Nexgard and we really dont feel safe with our Grandson around the topical or collarAny suggestions? My vet recommended the tablet to save on monthly costs for flea and tick treatment. Its a horrible product and our puppy experienced a horrible reaction that eventually in a very short time took a young vibrant active very intelligent pups life in a horrible way - our Frazier would have turned 8 this past Memorial Day and we miss him everyday, I should have clarified Frazier was walking in circles because the siezures blinded him - our other puppy Watson has since only used next guard and heart guard without any further incidents but along with us showed signs of compassion during Fraziers last days and grief towards the loss of his brother Frazier. So sorry! The costs associated with these two products are roughly the same. I PRAY that our baby is okay with this second dose. my dog became extremely itchy all over her body. The site is secure. Not grass grazing either. She does have history of seizures. This month 5/1 gave him another dose and here we are 12 days later with diarrhea and no appetite. Our vet recommended putting him on phenobarbital. But he had a terrifying seizure when I was out walking him on December 26, 2020 with no previous known history (he is rescue I've had since he was 2). The FDA considers products in the isoxazoline class to be safe and effective for dogs and cats but is providing this information so that pet owners and veterinarians can take it into consideration when choosing flea and tick products for their pets. Shortly after tablet I introduced sweet potatoes to diet per vet in lieu of potatoes. A heartworm test may be necessary in about six months (that's how long it takes heartworm larvae to mature enough to show up on a test). Hopefully, there is no permanent damage to his brain or body. So I did. Just wanted to share my experience in case anyone else has similar experience with dog's character changing. They did a blood test (this is literally 7 days later) and his ATL liver levels were off the charts at >2000. Gave my 28lb German Spitz her monthly prescibed dose of Simparica. I even said "I am reading a blog, right now, with pages of stories about this drug and the side effects". He is very whinny and is drinking a lot of water. She was shaking like she was freezing. she has shaking off and on . Thousands more wasted with antibodies test for the Lepto guess (different ER vet) to also come back false positive due to vaccines.. my poor baby already had a rough life being abandoned. I'm so sorry. After he was sent home, he was still not well and barely able to hold in any food and had to take any fluids intravenously. She passed away soon after taking this medication. The vet said the simparica didn't cause the disease but it could have been the link that pushed him into the Crisis. I have read that Simparica may cause side effects including muscle tremors, diarrhea, lethargy, anorexia, otitis externa, hyperactivity, neurological side effects, seizures, convulsions, anxiety and skin irritation . Sarolaner, one of the ingredients in SIMPARICA TRIO, is a member of the isoxazoline class. I'll be spreading the word. I thought maybe he got into something. My dog weighs 60 pounds and was given a dose for dogs up to 88 pounds. No more of this junk for my pups! If you miss a dose of Simparica Trio, give it immediately and resume monthly dosing. Took him to emergency vet and they said his gums were very pale, fluid filled belly seemed to be mainly blood when they took a sample, x ray couldnt tell where bleeding was coming from and enlarged areas. No vet writer or qualified reviewer has received any compensation from the manufacturer of the medication as part of creating this article. Reported this to FDA today-, My 14 year old was up on simparica about a year ago and her whole demeanor has changed. My 1 year old Italian Spinone puppy has been losing hair on her back and has a big ear infection. He is my first dog, he is 5yrs old now, and this is all new. We received the first dose of this medication from our Vet! Yea so what about the 10 percent? Wonder why PetSmart offers this if there are so many concerns reported. Simparica has possibly shown no severe side effects that may concern the health of dogs. I would notice he gets super tired walking and would go limp in my arms. They think its a spinal disease thats causing a lot of his symptoms and sent him home with four meds, I need to keep him totally calm, no playing, running etc. I hope these steps will prevent anyone else's pet having to endure this. She still has her appetite at the moment. It seems to be clearing up with Rx eye drops. Does your do still have a cough? Our 6 year old, 66# Treeing Walker Coon Hound baby has been taking Simparica for about two years. After your dog takes the chew, the drugs circulate in the blood, and when a flea or tick bites your dog, it's exposed to the chemical. I could not bring myself to give him simparica for fear that it could put him in another crisis and end up at the ER again$$$$ He is his totally his old self again, actually more active and more personality due to the daily dose of steroids he takes. The vet office called simparica hotline to find out if it was safe to give her another one. Im seeing an improvement in my dog, and am crossing fingers that this continues! He eats and drinks fine but looks like we havent fed him in days. Has anyones dog stopped having seizures when the medication wore off or is this going to be a permanent issue possibly getting worse? That night he seemed a little uncomfortable, unable to sleep, and I didnt think anything of it. Ticks are horrible here in Maine. He is pissing a lot and often and drinking a lot of water. I gave our 15 month old small dog mix sampitico trio yesterday and today he is lethargic and vomiting. After realizing that the only thing that we did differently was to give him his first dose of Simperica, my wife began research and came across this conversation. She spent 4 nights at the University of Auburn emergency room and vet clinic. If my dog dies, which does not look too good right now for him, I will stop at nothing to make the company's life miserable. Will this ever get better as the med wears down? The door is open , its where he prefers to sleep on a doggie bed . 98. If these symptoms appear on your pet, do not worry, it is normal after taking a dose of Simparica. My dog is having the same issues. Bentlee trusts me an I let him down on this one. Other adverse reactions like lethargy, anorexia, itching, and increased thirst are possible but not very likely. She has had tremors, very lethargic, drinking lots of water. How long did the itchiness last for your schnauzer? It was the first time she had taken Simparica. You don't think I'm going to continue with this poison. If most side effects are mild, ( vomiting 12 hours later could be due to other things the dog has eaten within those 12 hours), I am ok with that. Simparica Trio is the brand name of a chewable tablet that protects dogs from heartworm disease, fleas, five species of ticks, and two types of intestinal parasites. He is also running a fever so is not out of the woods. I am worried! The issues started within 24 hours of the dose and continue. Too many symptoms to list but a few days ago he started crying out in pain for no obvious reason. The excerpts below from the manufacturers' Prescribing . The older of the 2 Poodles seemed to do fine but my younger Poodle who was about 3 years old was definitely affected and we had a difficult time even getting him to eat for at least 2 weeks. So the next day was Saturday , me & my husband got up early . like she wants me to fix it. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water). Linda. Thank you for this. Side effects are rare and may include: Vomiting Lethargy Diarrhea Loss of appetite Neurologic side effects have been seen after using medications in this class of drugs. They gave him IV glucose to raise his Potassium level. Next day, he was suddenly 1000% worse, would not touch food, could not move. In some dogs, Simparica may cause abnormal neurologic signs such as: Tremors and Seizures. Vet trip and meds $400! We gave our 13 yr old lab mix this medicine as our doctor doesn't carry trifexis anymore. Hi Laura, just wondering what supplements you gave your pup to help and how long it took for her to get back to herself after simparica. 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Took this pill on August 8th giving the MED to my 8 yr old lab mix this medicine was!... 6 years old ) has been taking Simparica for my newly adopted Chihuahua yesterday 'm on hour.

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