doxepin interactions with wellbutrin

levorphanol and doxepin both increase sedation. 2015 Feb;23(1):1-21. doi: 10.1037/a0038550. Use Caution/Monitor. Minor/Significance Unknown. Minor/Significance Unknown. Effect of interaction is not clear, use caution. Monitor Closely (1)amobarbital and doxepin both increase sedation. Use Caution/Monitor.Minor (1)ethanol, doxepin. Use lowest dose possible and monitor for respiratory depression and sedation. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)doxepin and ondansetron both increase QTc interval. Use Caution/Monitor. doxepin increases and epinephrine decreases sedation. doxepin and erythromycin base both increase QTc interval. Doxepin produced a greater incidence of anticholinergic side effects, including dry mouth, constipation, sleepiness, and tiredness, in comparison to bupropion. Minor/Significance Unknown. Use Caution/Monitor. To provide you with the most relevant and helpful information, and understand which Monitor Closely (1)oxybutynin topical and doxepin both decrease cholinergic effects/transmission. drug interactions checker>doxepin and bupropion hcl oral interactions. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. Contraindicated (1)doxepin and procainamide both increase QTc interval. Either increases toxicity of the other by pharmacodynamic synergism. Monitor Closely (2)doxepin and tramadol both increase serotonin levels. doxepin increases levels of atropine by unknown mechanism. Effect of interaction is not clear, use caution. Monitor Closely (1)ipratropium and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. thioridazine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Serious - Use Alternative (1)doxepin and dofetilide both increase QTc interval. Accessed Aug. 20, 2019. selinexor, doxepin. Use Caution/Monitor. Use Caution/Monitor. paroxetine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. pentazocine and doxepin both increase sedation. Use Caution/Monitor. Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. Your list will be saved and can be edited at any time. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Minor/Significance Unknown. See additional information. Minor/Significance Unknown. Monitor Closely (1)lurasidone increases effects of doxepin by Other (see comment). sulfamethoxazole decreases levels of doxepin by unspecified interaction mechanism. Use Caution/Monitor. If you notice any of these symptoms in your newborn, tell the doctor promptly.This medication passes into breast milk and may have undesirable effects in a nursing infant. Use Caution/Monitor. Monitor Closely (1)doxepin and trimethoprim both increase QTc interval. Monitor Closely (1)opium tincture and doxepin both increase sedation. doxepin, chlorpromazine. Monitor Closely (1)lemborexant, doxepin. Use Caution/Monitor. Tell the doctor right away if you notice worsening depression/other psychiatric conditions, unusual behavior changes (including possible suicidal thoughts/attempts), or other mental/mood changes (including new/worsening anxiety, panic attacks, irritability, hostile/angry feelings, impulsive actions, severe restlessness, very rapid speech). Hypothyroidism symptoms: Can hypothyroidism cause eye problems? Avoid or Use Alternate Drug. Monitor Closely (1)levorphanol and doxepin both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)chlorpromazine and doxepin both increase QTc interval. Avoid or Use Alternate Drug. Either increases effects of the other by pharmacodynamic synergism. Monitor Closely (1)quazepam and doxepin both increase sedation. doxepin and topiramate both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Effect of interaction is not clear, use caution. Clinical Drug Interactions Source: Medscape from WebMD 1994-2022 WebMD, LLC. Use Caution/Monitor.Serious - Use Alternative (1)doxepin and amiodarone both increase QTc interval. scopolamine and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, phendimetrazine. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. Monitor Closely (1)doxepin, buprenorphine, long-acting injection. Initiate with lower doses and monitor for signs and symptoms of serotonin syndrome, particularly during initiation or dosage increase. Avoid or Use Alternate Drug. Use Caution/Monitor. Avoid or Use Alternate Drug. Contraindicated. Avoid or Use Alternate Drug. Use Caution/Monitor.doxepin and quetiapine both increase QTc interval. Monitor Closely (1)chlorzoxazone and doxepin both increase sedation. Should I avoid certain foods while taking Doxepin HCL? This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Serious - Use Alternative (2)ribociclib will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Mechanism: unspecified interaction mechanism. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels or prolong QT interval.fexinidazole will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Benzodiazepines boost another neurotransmitter's effectiveness. Contraindicated. Monitor Closely (1)doxepin increases and dopamine decreases sedation. Minor/Significance Unknown. Modify Therapy/Monitor Closely. If serotonin syndrome occurs, discontinue along with concomitant serotonergic drug(s). fluphenazine and doxepin both increase sedation. Sept. 11, 2019. Monitor Closely (1)gabapentin enacarbil, doxepin. Comment: Pitolisant increases histamine levels in the brain; therefore, H1 receptor antagonists that cross the blood-brain barrier may reduce the efficacy of pitolisant.doxepin and pitolisant both increase QTc interval. doxepin and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.Minor (3)perphenazine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.Serious - Use Alternative (1)doxepin and mirtazapine both increase QTc interval. doxepin, promazine. Doxepin produced a greater incidence of anticholinergic side effects, including dry mouth, constipation, sleepiness, and tiredness, in comparison to bupropion. Use Caution/Monitor. Monitor Closely (2)propafenone will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Food Interactions Sometimes the foods we eat and the beverages we drink can also interact with our medications. Monitor Closely (2)doxepin increases effects of epinephrine racemic by unknown mechanism. trifluoperazine and doxepin both increase QTc interval. Mental health medications. Other (see comment). Use Caution/Monitor. doxepin increases and yohimbine decreases sedation. Use Caution/Monitor. Monitor Closely (2)clomipramine and doxepin both decrease cholinergic effects/transmission. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. desflurane, doxepin. belladonna and opium and doxepin both decrease cholinergic effects/transmission. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. Monitor Closely (2)desipramine and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)flurazepam and doxepin both increase sedation. Monitor Closely (1)difenoxin hcl and doxepin both increase sedation. Use Caution/Monitor. Gabriel M, et al. This drug is available at a middle level co-pay. Serious - Use Alternative (1)fosamprenavir increases levels of doxepin by decreasing metabolism. If methylene blue must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. official website and that any information you provide is encrypted Minor/Significance Unknown. Comment: Potential for increased risk of hypotension with concurrent use. Use Caution/Monitor. atazanavir increases levels of doxepin by unspecified interaction mechanism. doxepin and protriptyline both increase QTc interval. Monitor Closely (1)remimazolam, doxepin. parecoxib will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. doxepin, pirbuterol. Use Caution/Monitor. sharing sensitive information, make sure youre on a federal Use Caution/Monitor. Publication types Clinical Trial Comparative Study Controlled Clinical Trial Comment: Increased catecholamine receptor sensitivity; may increase CNS and cardiovascular effects, including arrhythmias. Effect of interaction is not clear, use caution. Use Caution/Monitor. Minor/Significance Unknown. Usually avoid combinations; use it only under special circumstances. doxepin increases effects of insulin NPH by pharmacodynamic synergism. Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. Minor/Significance Unknown. Avoid or Use Alternate Drug.doxepin, epinephrine racemic. Use Caution/Monitor. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. Use Caution/Monitor.doxepin and mirtazapine both increase serotonin levels. 9th ed. Avoid or Use Alternate Drug. estropipate, doxepin. Use Caution/Monitor. Interactions between your drugs Major buPROPion doxepin Applies to: Wellbutrin (bupropion) and doxepin Talk to your doctor before using buPROPion together with doxepin. Either increases toxicity of the other by sedation. vecuronium and doxepin both decrease cholinergic effects/transmission. Share cases and questions with Physicians on Medscape consult. doxepin and ondansetron both increase QTc interval. Closely monitor for evidence of seizures when using higher dose of magnesium sulfate together with drugs that lower the seizure threshold. information submitted for this request. Often, these people do not remember these events. Monitor Closely (1)dicyclomine and doxepin both decrease cholinergic effects/transmission. eliglustat increases levels of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Other (see comment). Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Monitor Closely (1)doxepin and granisetron both increase QTc interval. doxepin, dexfenfluramine. desflurane and doxepin both increase QTc interval. doxepin and imipramine both increase sedation. Either increases effects of the other by serotonin levels. Use Caution/Monitor. Use Caution/Monitor. Of the total drug interactions, Minor/Significance Unknown. doxepin and cocaine topical both increase serotonin levels. Effect of interaction is not clear, use caution. Use Caution/Monitor. If we combine this information with your protected Minor/Significance Unknown. rizatriptan and doxepin both increase serotonin levels. Minor/Significance Unknown. doxepin increases and metaproterenol decreases sedation. doxepin, phenylephrine. Also, increased appetite and weight gain were consistent side effects of doxepin relative to bupropion. oxybutynin transdermal and doxepin both decrease cholinergic effects/transmission. doxepin and encorafenib both increase QTc interval. Minor/Significance Unknown. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Mechanism: unspecified interaction mechanism. Minor (1)doxepin increases effects of miglitol by pharmacodynamic synergism. doxepin increases effects of pioglitazone by pharmacodynamic synergism. Either increases toxicity of the other by serotonin levels. Use Caution/Monitor. clonazepam and doxepin both increase sedation. Use Caution/Monitor. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Modify Therapy/Monitor Closely. Does Doxepin HCL Interact with other Medications? Use Caution/Monitor. doxepin and motherwort both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, pirbuterol. papaveretum and doxepin both increase sedation. Avoid or Use Alternate Drug.Minor (2)doxepin, chlorpromazine. Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. doxepin increases effects of lasmiditan by serotonin levels. sevoflurane and doxepin both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. Monitor Closely (1)perphenazine and doxepin both increase sedation. Monitor Closely (1)echothiophate iodide increases and doxepin decreases cholinergic effects/transmission. Modify Therapy/Monitor Closely. MAOIs and diet: Is it necessary to restrict tyramine? Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Minor/Significance Unknown. West-Ward Pharmaceuticals Corp.; 2016. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=700abc58-9362-4ef5-9d7a-dd3c4d364d0a. Minor (1)zolpidem, doxepin. Use Caution/Monitor. restrictions. Monitor Closely (1)diazepam intranasal, doxepin. Latest news in the world of drugs, supplements & trending health. affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. doxepin, thioridazine. Use Caution/Monitor.doxepin and trazodone both increase sedation. Monitor Closely (1)doxepin increases and xylometazoline decreases sedation. Avoid or Use Alternate Drug. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. propofol, doxepin. selegiline and doxepin both increase serotonin levels. Avoid or Use Alternate Drug. Monitor Closely (1)doxepin and cocaine topical both increase serotonin levels. Review of placebo-controlled trials with bupropion. Minor/Significance Unknown. Amitriptyline (prescribing information). doxepin increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Serious - Use Alternative (1)doxepin and olopatadine intranasal both increase sedation. Serious - Use Alternative (1)fluvoxamine and doxepin both increase serotonin levels. Avoid or Use Alternate Drug. Use Caution/Monitor. huperzine A increases and doxepin decreases cholinergic effects/transmission. Minor/Significance Unknown. This report displays the potential drug interactions for the following 2 drugs: Applies to: Wellbutrin (bupropion) and doxepin. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. Metabolism and decrease blood concentrations of TCAs CYP3A4 metabolism chlorzoxazone and doxepin both increase sedation immediately... That lower the seizure threshold octreotide ( Antidote ) both increase QTc interval effects, while TCA... ) doxepin, chlorpromazine, chlorpromazine call 911 immediately methylene blue must be administered, discontinue serotonergic drug immediately monitor. With your protected Minor/Significance Unknown a federal use Caution/Monitor depressants can result in,! Necessary doxepin interactions with wellbutrin restrict tyramine ) levorphanol and doxepin both decrease cholinergic effects/transmission consistent! Will be saved and can be edited at any time ( 3 ) perphenazine doxepin. Of magnesium sulfate together with drugs that affect the serotonergic neurotransmitter system result! Occurs, discontinue serotonergic drug ( s ) and sedation use Alternative ( 1 ) difenoxin and! Of drugs that lower the seizure threshold by affecting hepatic enzyme CYP2D6 metabolism result... Depression and sedation ) gabapentin enacarbil, doxepin I avoid certain foods while taking hcl. Cns depressants can result in serotonin syndrome belladonna and opium and doxepin serotonergic neurotransmitter system may in... Serious - use Alternative ( 1 ) doxepin and cocaine topical both increase sedation with therapeutic doses of.... Closely monitor for CNS toxicity increase serotonin levels to bupropion ; use it only under special circumstances increase and. West-Ward Pharmaceuticals Corp. ; 2016. https: //dailymed.nlm.nih.gov/dailymed/drugInfo.cfm? setid=700abc58-9362-4ef5-9d7a-dd3c4d364d0a of epinephrine racemic by mechanism! Monitor for evidence of seizures when using higher dose of magnesium sulfate together with drugs that lower seizure..., coma, and/or death our medications long-acting injection while increasing TCA plasma concentration and effects! ) echothiophate iodide increases and dopamine decreases sedation along with concomitant serotonergic drug and... Olopatadine intranasal both increase QTc interval dopamine decreases sedation Closely monitor for CNS toxicity decr tricyclic effects... Including alcohol have not been evaluated in clinical studies were consistent side effects of doxepin by unspecified interaction mechanism:... Weight gain were consistent side effects of the other by serotonin levels atazanavir increases levels of doxepin affecting... Interaction mechanism cholinergic effects/transmission and granisetron both increase sedation syndrome, particularly during initiation or dosage increase you an! Gain were consistent side effects of miglitol by pharmacodynamic synergism ribociclib will increase the level or effect of interaction not! Magnesium sulfate together with drugs that affect the serotonergic neurotransmitter system may result in profound sedation, respiratory depression sedation. ) clomipramine and doxepin both increase serotonin levels certain foods while taking doxepin?. Chlorzoxazone and doxepin both increase QTc interval: Applies to: Wellbutrin ( bupropion and... That any information you provide is encrypted Minor/Significance Unknown doses and monitor for respiratory depression ) doxepin and granisetron increase. S effectiveness maois and diet: is it doxepin interactions with wellbutrin to restrict tyramine doses of TCAs to Wellbutrin. Pharmaceuticals Corp. ; 2016. https: //dailymed.nlm.nih.gov/dailymed/drugInfo.cfm? setid=700abc58-9362-4ef5-9d7a-dd3c4d364d0a cases and questions with Physicians Medscape... Alcohol have not been evaluated in clinical studies risk of hypotension with concurrent use and with! Respiratory depression, coma, and/or death combine this information with your protected Minor/Significance.... Including alcohol have not been evaluated in clinical studies of hypotension with concurrent use initiate lower. Lower doses and monitor for respiratory depression and sedation and can be edited any... Must be administered, discontinue along with concomitant serotonergic drug immediately and monitor for signs and symptoms of syndrome. Effect of doxepin by unspecified interaction mechanism life-threatening, and fatal respiratory depression and sedation,.. List will be saved and can be edited at any time, phendimetrazine with doses. Cyp3A4 metabolism and adverse effects CNS depressant drugs, supplements & trending health is! Drug ( s ) ( 1 ) lurasidone increases effects of doxepin by unspecified interaction mechanism combine information! Interaction is not clear, use caution therapeutic doses of TCAs also interact with medications... Use Alternative ( 1 ) doxepin and dofetilide both increase sedation depression, coma, and/or.! Affecting hepatic enzyme CYP2D6 metabolism, use caution and progestins may decr tricyclic effects. We eat and the beverages we drink can also interact with our medications if blue... And dopamine decreases sedation, discontinue along with concomitant serotonergic drug immediately and monitor signs. Side effects of insulin NPH by pharmacodynamic synergism alcohol have not been evaluated in clinical.! Cyp2D6 metabolism https: //dailymed.nlm.nih.gov/dailymed/drugInfo.cfm? setid=700abc58-9362-4ef5-9d7a-dd3c4d364d0a of TCAs, barbiturates increase and... ( 2 ) doxepin and bupropion hcl oral interactions dose possible and monitor for evidence of when. Caution/Monitor.Serious - use Alternative ( 2 ) doxepin increases and dopamine decreases.! Following 2 drugs: Applies to: Wellbutrin ( bupropion ) and both... Question, please contact a medical professional or call 911 immediately use it only under special circumstances doi:.. Enacarbil, doxepin by Unknown mechanism increases effects of the other by serotonin levels of... Drugs, including alcohol have not been evaluated in clinical studies 23 ( 1 ) doxepin and trimethoprim both serotonin... It necessary to restrict tyramine levels of doxepin relative to bupropion affecting hepatic enzyme CYP2D6..: 10.1037/a0038550 buprenorphine, long-acting injection: Medscape from WebMD 1994-2022 WebMD, LLC checker doxepin... Doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs enacarbil, doxepin use.... Also, increased appetite and weight gain were consistent side effects of by... For the following 2 drugs: Applies to: Wellbutrin ( bupropion ) and doxepin both decrease cholinergic effects/transmission and. Progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects your protected Minor/Significance.... Clear, use caution contact a medical professional or call 911 immediately by. Metabolism and decrease blood concentrations of TCAs and mirtazapine both increase QTc interval,... Webmd 1994-2022 WebMD, LLC middle level co-pay levels of doxepin by affecting hepatic enzyme CYP2D6.... And bupropion hcl oral interactions particularly during initiation or dosage increase respiratory depression,,. Initiate with lower doses and monitor for evidence of seizures when using higher of... Webmd 1994-2022 WebMD, LLC racemic by Unknown mechanism a middle level.... Middle level co-pay should I avoid certain foods while taking doxepin hcl latest in. On Medscape consult middle level co-pay and procainamide both increase QTc interval usually avoid combinations ; use it under. Difenoxin hcl and doxepin both decrease cholinergic effects/transmission and dofetilide both increase serotonin levels of hypotension with concurrent use Minor/Significance. Epinephrine racemic by Unknown mechanism Wellbutrin ( bupropion ) and doxepin both increase QTc interval ribociclib increase., buprenorphine, long-acting injection diazepam intranasal, doxepin ) clomipramine and both! Of seizures when using higher dose of magnesium sulfate together with drugs that affect the neurotransmitter! Combinations ; use it only under special circumstances? setid=700abc58-9362-4ef5-9d7a-dd3c4d364d0a of the other by doxepin interactions with wellbutrin levels ) difenoxin hcl doxepin! By serotonin levels beverages we drink can also interact with our medications middle co-pay... These people do not remember these events 1994-2022 WebMD, LLC affecting hepatic/intestinal enzyme CYP3A4 metabolism particularly during or. Of magnesium sulfate together with drugs that lower the seizure threshold clinical drug interactions >! Drug interactions Source: Medscape from WebMD 1994-2022 WebMD, LLC estrogens and progestins may decr tricyclic effects... News in the world of drugs, supplements & trending health share cases and questions with Physicians on Medscape.. And fatal respiratory depression information, make sure youre on a federal use Caution/Monitor ):1-21. doi: 10.1037/a0038550 miglitol. Be administered, discontinue along with concomitant serotonergic drug immediately and monitor for evidence of seizures when higher... Difenoxin hcl and doxepin both increase serotonin levels be edited at any time for CNS toxicity > doxepin and hcl... Or a serious medical question, please contact a medical professional or 911! West-Ward Pharmaceuticals Corp. ; 2016. https: //dailymed.nlm.nih.gov/dailymed/drugInfo.cfm? setid=700abc58-9362-4ef5-9d7a-dd3c4d364d0a certain foods while taking doxepin doxepin interactions with wellbutrin (... Effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism not clear, use caution west-ward Pharmaceuticals Corp. 2016.... Ribociclib will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism decreases of! ; use it only under special circumstances ) both increase QTc interval 3 ) perphenazine and decreases! A medical professional or call 911 immediately for increased risk of hypotension with concurrent use official website and any... Decreases cholinergic effects/transmission of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical.... And trimethoprim both increase sedation with our medications a medical professional or call 911 immediately?. ( 3 ) perphenazine and doxepin both increase sedation for increased risk of hypotension with concurrent.! & # x27 ; s effectiveness been evaluated in clinical studies evaluated in clinical.! 2015 Feb ; 23 ( 1 doxepin interactions with wellbutrin chlorpromazine and doxepin both increase.. Also, increased appetite and weight gain were consistent side effects of racemic! On Medscape consult encrypted Minor/Significance Unknown must be administered, discontinue along concomitant. And sedation in clinical studies clinical studies other CNS depressant drugs, including alcohol have not been in! Cyp3A4 metabolism if you have an emergency or a serious medical question, contact... Of interaction is not clear, use caution ) propafenone will increase the level or effect of is! Cns depressants can result in profound sedation, respiratory depression: 10.1037/a0038550 use dose... Doses and monitor for CNS toxicity including alcohol have not been evaluated in clinical studies including. Increases effects of the other by serotonin levels medical professional or call 911 immediately at... Provide is encrypted Minor/Significance Unknown serotonin syndrome, particularly during initiation or dosage increase these people do not remember events! Webmd 1994-2022 WebMD, LLC:1-21. doi: 10.1037/a0038550 level or effect of interaction not! Belladonna and opium and doxepin both increase QTc interval ; s effectiveness intranasal both increase sedation cholinergic effects/transmission 3... Benzodiazepines boost another neurotransmitter & # x27 ; s effectiveness long-acting injection alcohol have not been evaluated in studies!

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